Open AccessComparison of low-molecular weight heparins to unfractionated heparin
Author(s) -
Johann Auer
Publication year - 2001
Publication title -
european heart journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.336
H-Index - 293
eISSN - 1522-9645
pISSN - 0195-668X
DOI - 10.1053/euhj.2001.2551
Subject(s) - medicine , heparin , low molecular weight heparin , pharmacology
Mechanism of anticoagulation Activates antithrombin III*; equivalent activity against factor Xa and thrombin; releases TFPI from endothelium; unable to inactivate clot-bound thrombin or FDP; inactivates fluid-phase thrombin Less activation of antithrombin III; greater activity against factor Xa than thrombin; releases TFPI from endothelium; unable to inactivate clotbound thrombin or FDP; weaker inactivation of fluid-phase thrombin
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