The human G-protein β3 subunit C825T polymorphism is associated with coronary artery vasoconstriction | Zendy

Aline Meirhaeghe | Zendy

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The human G-protein β3 subunit C825T polymorphism is associated with coronary artery vasoconstriction

Author(s) -

Aline Meirhaeghe

Publication year - 2001

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1053/euhj.2000.2400

Subject(s) - medicine , vasoconstriction , cardiology , protein subunit , genetics , gene , biology

Abnormal coronary vasomotion plays a role in the clinical expression of coronary artery disease. We hypothesized that the functional C825T polymorphism located in the ubiquitous G-protein beta3 subunit, implicated in the cellular signal transduction of many receptors, could modify artery coronary vasomotion. We assessed the potential association of the pertussis toxin-sensitive G protein beta3 subunit (GNB3) gene C825T polymorphism on coronary vasomotion in humans.

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