Effects of KATPchannel blockade by glibenclamide on the warm-up phenomenon | Zendy

Fabrizio Tomai | Zendy

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Effects of KATPchannel blockade by glibenclamide on the warm-up phenomenon

Author(s) -

Fabrizio Tomai

Publication year - 1999

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1053/euhj.1998.1311

Subject(s) - medicine , glibenclamide , placebo , heart rate , blood pressure , saline , coronary artery disease , anesthesia , rate pressure product , ischemia , cardiology , endocrinology , diabetes mellitus , alternative medicine , pathology

The increased tolerance to myocardial ischaemia observed during the second of two sequential exercise tests, i.e. the warm-up phenomenon, has been proposed as a clinical model of ischaemic preconditioning. As ATP-sensitive K+ channels appear to be a mediator of ischaemic preconditioning in both experimental and clinical studies, the aim of this study was to investigate the role of K(ATP) channels in the warm-up phenomenon.

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