Cyclin-dependent kinase inhibitor expression in human heart failure. A comparison with fetal development | Zendy

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Cyclin-dependent kinase inhibitor expression in human heart failure. A comparison with fetal development

Author(s) -

Paul Burton

Publication year - 1999

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1053/euhj.1998.1231

Subject(s) - medicine , fetus , heart failure , kinase , cyclin , cyclin dependent kinase 4 , cardiology , cancer research , microbiology and biotechnology , cyclin dependent kinase 2 , cell cycle , pregnancy , cancer , genetics , biology

Terminal differentiation of cardiac myocyte is associated with their permanent withdrawal from the cell cycle. In adult end-stage heart failure, significant numbers of myocytes express proliferating cell nuclear antigen yet fail to progress to cell division. Cyclin dependent kinase inhibitors are powerful inhibitors of the cell cycle and may play a direct role both in myocyte development and in preventing cell division in the adult.

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