Uric acid in chronic heart failure: a marker of chronic inflammation | Zendy

Francisco Leyva | Zendy

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Uric acid in chronic heart failure: a marker of chronic inflammation

Author(s) -

Francisco Leyva

Publication year - 1998

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1053/euhj.1998.1188

Subject(s) - medicine , uric acid , endocrinology , heart failure , inflammation , hyperuricemia , endothelial activation , creatinine , gout , xanthine oxidase , insulin resistance , diabetes mellitus , biochemistry , chemistry , enzyme

Chronic heart failure is associated with hyperuricaemia and elevations in circulating markers of inflammation. Activation of xanthine oxidase, through free radical release, causes leukocyte and endothelial cell activation. Associations could therefore be expected between serum uric acid level, as a marker of increased xanthine oxidase activity, and markers of inflammation. We have explored these associations in patients with chronic heart failure, taking into account the hyperuricaemic effects of diuretic therapy and insulin resistance.

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