Open AccessThe effectiveness of mineralized plasmatic matrix in the closure of alveolar clefts with volumetric assessment
Author(s) -
Padminii Ellapakurthi,
G. Sridhar Reddy
Publication year - 2021
Publication title -
regenerative medicine research
Language(s) - English
Resource type - Journals
ISSN - 2050-490X
DOI - 10.1051/rmr/210004
Subject(s) - medicine , platelet rich fibrin , dental alveolus , cone beam computed tomography , bone grafting , alveolar wall , platelet rich plasma , dentistry , reduction (mathematics) , soft tissue , fibrin , nuclear medicine , surgery , computed tomography , lung , platelet , geometry , mathematics , immunology
Objectives: The purpose of this study is to assess the effectiveness of mineralized plasmatic matrix in the soft tissue closure of naso-alveolar fistula, to estimate the postoperative bone fill and volume of the graft placed in the alveolar cleft defect using cone-beam computed tomography (CBCT) at 3rd- month and 6th- month. Material and methods: 10 patients, in the age group of 15‑30 years were included in this study. They were diagnosed with unilateral cleft lip and alveolus defects with or without a cleft palate requiring late secondary alveolar bone grafting. Alveolar cleft defects were closed with mineralized plasmatic matrix (MPM), a combination of autogenous iliac bone graft and platelet rich plasma (PRP) and platelet rich fibrin (PRF). Results: The mean defect volume pre-operatively is 0.75 cm 3 and at the end of 3rd-month postoperatively is 0.51 cm 3 and at 6th-month postoperatively is 0.27 cm 3 . The average percentage of bone fill between preoperative (A) & 3th- month postoperatively (B) is 33.4% and between 3rd-month (B) and 6th-month post operatively (C) is 49.5%. Conclusions: Utilization of this new matrix (MPM), has shown to be effective in the closure of the cleft defect, oro-nasal fistula and also reduction in the volume of the residual cleft defect seen with sequential cone-beam computed tomography (CBCT) radiographs.