Open AccessMicroARN et maladies rénales
Author(s) -
Lucile Amrouche,
Raja Bonifay,
Dany Anglicheau
Publication year - 2011
Publication title -
médecine/sciences/ms. médecine sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.157
H-Index - 27
eISSN - 1958-5381
pISSN - 0767-0974
DOI - 10.1051/medsci/2011274016
Subject(s) - philosophy , medicine
MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs, evolutionarily conserved, that post-transcriptionnaly regulate gene expression by promoting degradation or repressing translation of the targetted messenger RNA. Recent data suggest the implication of miRNAs in renal development, and in renal diseases pathophysiology including fibrogenesis, regulation of innate and adaptive immunity, autoimmune diseases and acute rejection of the renal allograft. Herein, we review the implication of miRNAs in renal pathophysiology.