The molecular mechanism of contrast-induced nephropathy (CIN) and its link to in vitro studies on iodinated contrast media (CM) | Zendy

JaiSing Yang | Zendy; Yan-Ru Peng | Zendy; Shih-Chang Tsai | Zendy; Yeu-Sheng Tyan | Zendy; ChiCheng Lu | Zendy; Hong-Yi Chiu | Zendy; YuJen Chiu | Zendy; Sheng-Chu Kuo | Zendy; Yuh-Feng Tsai | Zendy; Ping-Chin Lin | Zendy; FuuJen Tsai | Zendy

Open Access

The molecular mechanism of contrast-induced nephropathy (CIN) and its link to in vitro studies on iodinated contrast media (CM)

Author(s) -

JaiSing Yang,

Yan-Ru Peng,

Shih-Chang Tsai,

Yeu-Sheng Tyan,

ChiCheng Lu,

Hong-Yi Chiu,

YuJen Chiu,

Sheng-Chu Kuo,

Yuh-Feng Tsai,

Ping-Chin Lin,

FuuJen Tsai

Publication year - 2018

Publication title -

biomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.498

H-Index - 26

eISSN - 2211-8039

pISSN - 2211-8020

DOI - 10.1051/bmdcn/2018080101

Subject(s) - iodinated contrast , iodinated contrast media , nephropathy , medicine , contrast (vision) , iodine , contrast medium , osmotic concentration , pharmacology , chemistry , urology , endocrinology , radiology , computed tomography , organic chemistry , artificial intelligence , computer science , diabetes mellitus

Iodinated contrast media (iodinated CM) have increased ability to absorb x-rays and to visualize structures that normally are impossible to observe in a radiological examination. The use of iodinated CM may destory renal function, commonly known as contrast-induced nephropathy (CIN), which can result in acute renal failure (ARF). This review article mainly focuses on the following areas: (1) classifications of iodinated CM: ionic or non-ionic, high-osmolarity contrast media (HOCM), low-osmolarity contrast media (LOCM) and iso-osmolarity contrast media (IOCM); (2) an introduction to the physical and chemical properties of the non-ionic iodinated CM; (3) the management of anaphylactic reaction by iodinated CM; (4) a suggested single injection of adult doses and maximum dose for non-ionic iodinated CM; (5) the molecular mechanism of contrast-induced nephropathy (CIN); (6) In vitro studies on iodinated CM. Based on above information, this review article provide an insight for understanding the drug safety of iodinated CM.

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