Open AccessChemotherapy‐evoked Painful Peripheral Neuropathy
Author(s) -
Polomano Rosemary C.,
Bennett Gary J.
Publication year - 2001
Publication title -
pain medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.893
H-Index - 97
eISSN - 1526-4637
pISSN - 1526-2375
DOI - 10.1046/j.1526-4637.2001.002001008.x
Subject(s) - medicine , chemotherapy induced peripheral neuropathy , peripheral neuropathy , neuropathic pain , chemotherapy , neurotoxicity , paclitaxel , limiting , peripheral , vincristine , anesthesia , cancer chemotherapy , cancer , surgery , toxicity , cyclophosphamide , mechanical engineering , endocrinology , engineering , diabetes mellitus
Vincristine and paclitaxel, two of the most effective drugs in the battle against cancer, produce a dose‐limiting neurotoxicity that sometimes presents as a painful peripheral neuropathy. For the first time, investigators have been able to produce these chemotherapy‐evoked painful peripheral neuropathies in the laboratory rat. These new models have already begun to elucidate the causes of the neuropathic pain associated with these antineoplastic drugs, which will now make it possible to search for effective ways to prevent and treat it.