Open AccessQuantification of the Risk of Corticosteroid‐induced Diabetes Mellitus Among the Elderly
Author(s) -
Blackburn David,
Hux Janet,
Mamdani Muhammad
Publication year - 2002
Publication title -
journal of general internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.746
H-Index - 180
eISSN - 1525-1497
pISSN - 0884-8734
DOI - 10.1046/j.1525-1497.2002.10649.x
Subject(s) - medicine , corticosteroid , diabetes mellitus , confidence interval , relative risk , population , cohort study , cohort , endocrinology , environmental health
We conducted a population‐based cohort study using administrative databases to quantify the association between oral and inhaled corticosteroid use and onset of diabetes mellitus in the elderly. Proton pump inhibitor (PPI) users were used as a control group. Relative to PPI users ( N = 53,845), oral corticosteroid users ( N = 31,864) were more likely to develop diabetes (adjusted rate ratio [aRR], 2.31; 95% confidence interval [95% CI], 2.11 to 2.54); however, inhaled corticosteroid users ( N = 38,441) were not (aRR, 1.03; 95% CI, 0.93 to 1.14). The estimated number needed to harm for continuous use of oral corticosteroids relative to PPIs over 1, 2, and 3 years of use were 41, 23, and 16, respectively.