Open AccessPolymers that reduce intraperitoneal adhesion formation
Author(s) -
Falk K.,
Holmdahl L.,
Halvarsson M.,
Larsson K.,
Lindman B.,
Bengmark S.
Publication year - 1998
Publication title -
british journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.202
H-Index - 201
eISSN - 1365-2168
pISSN - 0007-1323
DOI - 10.1046/j.1365-2168.1998.00784.x
Subject(s) - adhesion , medicine , tissue adhesion , sphingomyelin , peritoneum , polymer , cellulose , saline , biophysics , surgery , pharmacology , anesthesia , biochemistry , organic chemistry , chemistry , biology , cholesterol
Background Viscous macromolecules and phospholipids have been shown to reduce postoperative adhesion formation. The ideal agent, or combination of agents, still remains to be identified. Methods The effect of hydrophobically modified ethyl (hydroxyethyl) cellulose (HM‐EHEC) and polyquarternium‐24 (LM‐200), two cellulose‐derived polymers, and of sphingomyelin, was examined in an animal model. Adhesions were induced in the parietal peritoneum in a standardized manner and quantity, and the morphology of adhesion formation was evaluated after 7 days. Results A significant reduction in adhesion formation was seen in animals receiving LM‐200 ( P = 0·013) and HM‐EHEC ( P = 0·012) as a short‐term treatment compared with controls given saline, but not in animals receiving sphingomyelin ( P = 0·733). Additional effects were seen in the animals receiving LM‐200 as a prolonged treatment ( P < 0·001) compared with controls. There was no difference in the magnitude of the inflammatory response between the groups. Conclusion These results suggest that hydrophobically modified polymers are efficient in reducing adhesions, without affecting the inflammatory response. © 1998 British Journal of Surgery Society Ltd