Open AccessUpper gastrointestinal disease in patients with familial adenomatous polyposis
Author(s) -
Wallace M. H.,
Phillips R. K. S.
Publication year - 1998
Publication title -
british journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.202
H-Index - 201
eISSN - 1365-2168
pISSN - 0007-1323
DOI - 10.1046/j.1365-2168.1998.00776.x
Subject(s) - medicine , familial adenomatous polyposis , disease , epidemiology , gastrointestinal cancer , colorectal cancer , cancer , medline , adenomatous polyposis coli , gastroenterology , surgery , political science , law
Background Upper gastrointestinal disease has become an important aspect in the management of patients with familial adenomatous polyposis (FAP). Methods A review of the literature was carried out using Medline. Epidemiology, pathology and treatment options are considered. Results and conclusion Despite the fact that over 90 per cent of patients with FAP develop duodenal adenomas, only 5 per cent go on to develop cancer. In the absence of methods to detect who is at risk of cancer, all patients undergo regular endoscopic surveillance at present. Chemoprevention in the form of drug therapy may be the answer to controlling the disease. © 1998 British Journal of Surgery Society Ltd