Mitochondrial calcium signalling and neurodegenerative diseases | Zendy

Elena Britti | Zendy; Fabien Delaspre | Zendy; Jordi Tamarit | Zendy; Joaquim Ros | Zendy

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Mitochondrial calcium signalling and neurodegenerative diseases

Author(s) -

Elena Britti,

Fabien Delaspre,

Jordi Tamarit,

Joaquim Ros

Publication year - 2018

Publication title -

neuronal signaling

Language(s) - English

Resource type - Journals

ISSN - 2059-6553

DOI - 10.1042/ns20180061

Subject(s) - calcium , mitochondrial permeability transition pore , mitochondrion , microbiology and biotechnology , calcium signaling , programmed cell death , cytosol , mptp , calcium metabolism , biology , mitochondrial membrane transport protein , apoptosis , chemistry , neuroscience , biochemistry , signal transduction , inner mitochondrial membrane , organic chemistry , dopaminergic , dopamine , enzyme

Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium buffering, meaning that mitochondrial calcium uptake and release is intimately related to cytosolic calcium concentrations. This review focuses on the proteins contributing to mitochondrial calcium homoeostasis, the roles of the mitochondrial permeability transition pore (MPTP) and mitochondrial calcium-activated proteins, and their relevance in neurodegenerative pathologies. It also covers alterations to calcium homoeostasis in Friedreich ataxia (FA).

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