Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology | Zendy

Sven Epple | Zendy; Afaf H. ElSagheer | Zendy; Tom Brown | Zendy

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Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology

Author(s) -

Sven Epple,

Afaf H. ElSagheer,

Tom Brown

Publication year - 2021

Publication title -

emerging topics in life sciences

Language(s) - English

Resource type - Journals

eISSN - 2397-8562

pISSN - 2397-8554

DOI - 10.1042/etls20210169

Subject(s) - synthetic biology , oligonucleotide , microbiology and biotechnology , nucleic acid , computational biology , bottleneck , biology , biochemical engineering , dna , computer science , engineering , genetics , embedded system

The modification of DNA or RNA backbones is an emerging technology for therapeutic oligonucleotides, synthetic biology and biotechnology. Despite a plethora of reported artificial backbones, their vast potential is not fully utilised. Limited synthetic accessibility remains a major bottleneck for the wider application of backbone-modified oligonucleotides. Thus, a variety of readily accessible artificial backbones and robust methods for their introduction into oligonucleotides are urgently needed to utilise their full potential in therapeutics, synthetic biology and biotechnology.

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