‘EngNT’ — Engineering live neural tissue for nerve replacement | Zendy

James B. Phillips | Zendy

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‘EngNT’ — Engineering live neural tissue for nerve replacement

Author(s) -

James B. Phillips

Publication year - 2021

Publication title -

emerging topics in life sciences

Language(s) - English

Resource type - Journals

eISSN - 2397-8562

pISSN - 2397-8554

DOI - 10.1042/etls20210085

Subject(s) - peripheral nerve , medicine , nerve repair , tissue engineering , translation (biology) , key (lock) , biomedical engineering , neuroscience , computer science , anatomy , psychology , biology , biochemistry , computer security , messenger rna , gene

Peripheral nerve injury can result in severe long-term disability and current clinical approaches for repairing large gaps rely on the nerve autograft. Engineered Neural Tissue (EngNT) has been developed to provide living aligned therapeutic cells in a stabilised collagen hydrogel, mimicking the key features of the autograft. This Perspective article will introduce the field and discuss the current stage of translation, highlighting the key opportunities for commercial and clinical development.

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