Cell therapy for cartilage repair | Zendy

Charlotte Hulme | Zendy; Jade Perry | Zendy; Helen S. McCarthy | Zendy; Karina T. Wright | Zendy; Martyn Snow | Zendy; Claire Mennan | Zendy; Sally Roberts | Zendy

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Cell therapy for cartilage repair

Author(s) -

Charlotte Hulme,

Jade Perry,

Helen S. McCarthy,

Karina T. Wright,

Martyn Snow,

Claire Mennan,

Sally Roberts

Publication year - 2021

Publication title -

emerging topics in life sciences

Language(s) - English

Resource type - Journals

eISSN - 2397-8562

pISSN - 2397-8554

DOI - 10.1042/etls20210015

Subject(s) - regenerative medicine , cell therapy , mesenchymal stem cell , medicine , cartilage , regeneration (biology) , adipose tissue , stromal cell , clinical trial , tissue engineering , bone marrow , cell , stem cell , pathology , biomedical engineering , biology , microbiology and biotechnology , anatomy , genetics

Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of tissues and organs, offers great hope for the future of medicine. Cell therapy for treating defects in articular cartilage has been an exemplar of translating this technology to the clinic, but it is not without its challenges. These include applying regulations, which were designed for pharmaceutical agents, to living cells. In addition, using autologous cells as the therapeutic agent brings additional costs and logistical challenges compared with using allogeneic cells. The main cell types used in treating chondral or osteochondral defects in joints to date are chondrocytes and mesenchymal stromal cells derived from various sources such as bone marrow, adipose tissue or umbilical cord. This review discusses some of their biology and pre-clinical studies before describing the most pertinent clinical trials in this area.

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