Systems modelling ageing: from single senescent cells to simple multi-cellular models | Zendy

Alvaro Martinez Guimera | Zendy; Ciaran Welsh | Zendy; Piero Dalle Pezze | Zendy; Nicola Fullard | Zendy; Glyn Nelson | Zendy; Mathilde Roger | Zendy; Stefan Przyborski | Zendy; Daryl P. Shanley | Zendy

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Systems modelling ageing: from single senescent cells to simple multi-cellular models

Author(s) -

Alvaro Martinez Guimera,

Ciaran Welsh,

Piero Dalle Pezze,

Nicola Fullard,

Glyn Nelson,

Mathilde Roger,

Stefan Przyborski,

Daryl P. Shanley

Publication year - 2017

Publication title -

essays in biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.351

H-Index - 66

eISSN - 1744-1358

pISSN - 0071-1365

DOI - 10.1042/ebc20160087

Subject(s) - context (archaeology) , simple (philosophy) , computer science , ageing , process (computing) , key (lock) , senescence , work (physics) , biochemical engineering , biological system , computational biology , biology , microbiology and biotechnology , engineering , mechanical engineering , paleontology , philosophy , genetics , computer security , epistemology , operating system

Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we discuss these issues and work through the process of building an integrated model for cellular senescence as a single cell and in a simple tissue context.

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