Polishing the tarnished silver bullet: the quest for new antibiotics | Zendy

Mark A. T. Blaskovich | Zendy; Mark S. Butler | Zendy; Matthew A. Cooper | Zendy

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Polishing the tarnished silver bullet: the quest for new antibiotics

Author(s) -

Mark A. T. Blaskovich,

Mark S. Butler,

Matthew A. Cooper

Publication year - 2017

Publication title -

essays in biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.351

H-Index - 66

eISSN - 1744-1358

pISSN - 0071-1365

DOI - 10.1042/ebc20160077

Subject(s) - silver bullet , antibiotics , business , stewardship (theology) , intensive care medicine , risk analysis (engineering) , antibiotic stewardship , drug , microbiology and biotechnology , biochemical engineering , medicine , biology , engineering , pharmacology , political science , antibiotic resistance , law , politics , sociology , anthropology

We are facing a potential catastrophe of untreatable bacterial infections, driven by the inexorable rise of extensively drug-resistant bacteria, coupled with a market failure of pharmaceutical and biotech companies to deliver new therapeutic options. While global recognition of the problem is finally apparent, solutions are still a long way from being implemented. In addition to drug stewardship programmes and better diagnostics, new antibiotics are desperately needed. The question remains as to how to achieve this goal. This review will examine the different strategies being applied to discover new antibiotics.

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