Lipotoxicity: a driver of heart failure with preserved ejection fraction? | Zendy

Jennifer Leggat | Zendy; Guillaume Bidault | Zendy; António Vidal-Puig | Zendy

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Lipotoxicity: a driver of heart failure with preserved ejection fraction?

Author(s) -

Jennifer Leggat,

Guillaume Bidault,

António Vidal-Puig

Publication year - 2021

Publication title -

clinical science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.91

H-Index - 138

eISSN - 1470-8736

pISSN - 0143-5221

DOI - 10.1042/cs20210127

Subject(s) - lipotoxicity , heart failure with preserved ejection fraction , medicine , heart failure , cardiology , context (archaeology) , diastole , ejection fraction , metabolic syndrome , obesity , blood pressure , insulin resistance , biology , paleontology

Heart failure with preserved ejection fraction (HFpEF) is a growing public health concern, with rising incidence alongside high morbidity and mortality. However, the pathophysiology of HFpEF is not yet fully understood. The association between HFpEF and the metabolic syndrome (MetS) suggests that dysregulated lipid metabolism could drive diastolic dysfunction and subsequent HFpEF. Herein we summarise recent advances regarding the pathogenesis of HFpEF in the context of MetS, with a focus on impaired lipid handling, myocardial lipid accumulation and subsequent lipotoxicity.

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