Extracellular RNA in kidney disease: moving slowly but surely from bench to bedside | Zendy

Robert W. Hunter | Zendy; Neeraj Dhaun | Zendy

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Extracellular RNA in kidney disease: moving slowly but surely from bench to bedside

Author(s) -

Robert W. Hunter,

Neeraj Dhaun

Publication year - 2020

Publication title -

clinical science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.91

H-Index - 138

eISSN - 1470-8736

pISSN - 0143-5221

DOI - 10.1042/cs20201092

Subject(s) - extracellular vesicles , extracellular , microvesicles , rna , bench to bedside , disease , extracellular vesicle , biology , computational biology , microbiology and biotechnology , medicine , microrna , pathology , genetics , gene , medical physics

We have known for just over a decade that functional RNA is shuttled between cells (Nat. Cell Biol. (2007) 9, 654-659). In that short time, there have been countless reports of extracellular RNA (exRNA) and extracellular vesicles (EVs) participating in diverse biological processes in development (Dev. Cell (2017) 40, 95-103), homoeostasis (Nature (2017) 542, 450-455) and disease (Nature (2017) 546, 498-503). Unsurprisingly - as these disciplines are still in their infancies - most of this work is still in the 'discovery biology' phase. However, exRNA and EVs show promise as disease biomarkers and could be harnessed in novel therapies.

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