SARS-CoV2 may evade innate immune response, causing uncontrolled neutrophil extracellular traps formation and multi-organ failure | Zendy

Alain R. Thierry | Zendy; Benoît Roch | Zendy

Open Access

SARS-CoV2 may evade innate immune response, causing uncontrolled neutrophil extracellular traps formation and multi-organ failure

Author(s) -

Alain R. Thierry,

Benoît Roch

Publication year - 2020

Publication title -

clinical science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.91

H-Index - 138

eISSN - 1470-8736

pISSN - 0143-5221

DOI - 10.1042/cs20200531

Subject(s) - innate immune system , neutrophil extracellular traps , immune system , immunology , biology , inflammation

We demonstrate that the general clinical conditions, risk factors and numerous pathological and biological features of COVID-19 are analogous with various disorders caused by the uncontrolled formation of neutrophil extracellular traps and their by-products. Given the rapid evolution of this disease's symptoms and its lethality, we hypothesize that SARS-CoV2 evades innate immune response causing COVID-19 progresses under just such an amplifier loop, leading to a massive, uncontrolled inflammation process. This work allows us to propose new strategies for treating the pandemic.

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