Open AccessMetabolomics reveals the impact of Type 2 diabetes on local muscle and vascular responses to ischemic stress
Author(s) -
Joshua A. Beckman,
JiunRuey Hu,
Shi Huang,
Eric FarberEger,
Quinn S. Wells,
Thomas J. Wang,
Robert E. Gerszten,
Jane F. Ferguson
Publication year - 2020
Publication title -
clinical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.91
H-Index - 138
eISSN - 1470-8736
pISSN - 0143-5221
DOI - 10.1042/cs20191227
Subject(s) - metabolite , medicine , endocrinology , ischemia , orotic acid , brachial artery , type 2 diabetes mellitus , type 2 diabetes , vasodilation , diabetes mellitus , blood pressure
Type 2 diabetes mellitus (T2DM) reduces exercise capacity, but the mechanisms are incompletely understood. We probed the impact of ischemic stress on skeletal muscle metabolite signatures and T2DM-related vascular dysfunction.
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