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We read with great interest the recent article by Thompson and colleagues [1] which reported the effects of inhibiting protein tyrosine phosphatase 1B (PTP1B) on the development of atherosclerosis within low-density lipoprotein receptor deficient (LDLR−/−) mice receiving either chow or high-fat diet. In this study, the authors conducted two experiments in which mice received single or five doses of the specific PTP1B inhibitor, trodusquemine. In both experiments, the investigators reported that when compared with controls, mice receiving trodusquemine exhibited a significant decrease in weight gain paralleled …

clinical science

Comment on ‘Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR−/− mouse model of atherosclerosis’