PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases | Zendy

Xuemin He | Zendy; Rui Cheng | Zendy; Siribhinya Benyajati | Zendy; Jianxing Ma | Zendy

Open Access

PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases

Author(s) -

Xuemin He,

Rui Cheng,

Siribhinya Benyajati,

Jianxing Ma

Publication year - 2015

Publication title -

clinical science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.91

H-Index - 138

eISSN - 1470-8736

pISSN - 0143-5221

DOI - 10.1042/cs20130463

Subject(s) - pedf , serpin , angiogenesis , inflammation , hypoxia (environmental) , biology , neuroscience , neuroprotection , pathological , immunology , medicine , cancer research , chemistry , genetics , gene , organic chemistry , oxygen

Pigment epithelium-derived factor (PEDF) is a broadly expressed multifunctional member of the serine proteinase inhibitor (serpin) family. This widely studied protein plays critical roles in many physiological and pathophysiological processes, including neuroprotection, angiogenesis, fibrogenesis and inflammation. The present review summarizes the temporal and spatial distribution patterns of PEDF in a variety of developing and adult organs, and discusses its functions in maintaining physiological homoeostasis. The major focus of the present review is to discuss the implication of PEDF in diabetic and hypoxia-induced angiogenesis, and the pathways mediating PEDF's effects under these conditions. Furthermore, the regulatory mechanisms of PEDF expression, function and degradation are also reviewed. Finally, the therapeutic potential of PEDF as an anti-angiogenic drug is briefly summarized.

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