Not just a writer: PRC2 as a chromatin reader | Zendy

Michael Uckelmann | Zendy; Chen Davidovich | Zendy

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Not just a writer: PRC2 as a chromatin reader

Author(s) -

Michael Uckelmann,

Chen Davidovich

Publication year - 2021

Publication title -

biochemical society transactions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.562

H-Index - 144

eISSN - 1470-8752

pISSN - 0300-5127

DOI - 10.1042/bst20200728

Subject(s) - chromatin , prc2 , epigenetics , context (archaeology) , bivalent chromatin , biology , genetics , chromatin remodeling , microbiology and biotechnology , ezh2 , gene , paleontology

PRC2 deposits the H3K27me3 repressive mark, which facilitates transcription repression of developmental genes. The decision of whether a particular gene is silenced at a given point during development is heavily dependent on the chromatin context. More than just a simple epigenetic writer, PRC2 employs several distinct chromatin reading capabilities to sense the local chromatin environment and modulate the H3K27me3 writer activity in a context-dependent manner. Here we discuss the complex interplay of PRC2 with the hallmarks of active and repressive chromatin, how it affects H3K27me3 deposition and how it guides transcriptional activity.

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