Oxysterol research: a brief review | Zendy

William J. Griffiths | Zendy; Yuqin Wang | Zendy

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Oxysterol research: a brief review

Author(s) -

William J. Griffiths,

Yuqin Wang

Publication year - 2019

Publication title -

biochemical society transactions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.562

H-Index - 144

eISSN - 1470-8752

pISSN - 0300-5127

DOI - 10.1042/bst20180135

Subject(s) - oxysterol , disease , neuroscience , mechanism (biology) , hedgehog signaling pathway , medicine , biology , cholesterol , signal transduction , microbiology and biotechnology , philosophy , epistemology

In the present study, we discuss the recent developments in oxysterol research. Exciting results have been reported relating to the involvement of oxysterols in the fields of neurodegenerative disease, especially in Huntington's disease, Parkinson's disease and Alzheimer's disease; in signalling and development, in particular, in relation to Hedgehog signalling; and in cancer, with a special focus on (25R)26-hydroxycholesterol. Methods for the measurement of oxysterols, essential for understanding their mechanism of action in vivo , and valuable for diagnosing rare diseases of cholesterol biosynthesis and metabolism are briefly considered.

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