Nucleotide modifications in messenger RNA and their role in development and disease | Zendy

Veronica Dezi | Zendy; Chavdar Ivanov | Zendy; Irmgard U. Haussmann | Zendy; Matthias Soller | Zendy

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Nucleotide modifications in messenger RNA and their role in development and disease

Author(s) -

Veronica Dezi,

Chavdar Ivanov,

Irmgard U. Haussmann,

Matthias Soller

Publication year - 2016

Publication title -

biochemical society transactions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.562

H-Index - 144

eISSN - 1470-8752

pISSN - 0300-5127

DOI - 10.1042/bst20160110

Subject(s) - messenger rna , rna , biology , gene , nucleotide , computational biology , genetics , function (biology)

Modified nucleotides in messenger RNA (mRNA) have been discovered over 40 years ago, but until recently little was known about which transcripts contain them and what their function is. High-throughput sequencing approaches revealed a dynamic landscape of the 'Epitranscriptome' for many mRNA modifications in various organisms from yeast to humans. Meanwhile, also many genes encoding mRNA-modifying enzymes and auxiliary proteins have been identified yielding functional insights by reverse genetics into their role in development and disease.

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