Isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), fumarate hydratase (FH): three players for one phenotype in cancer? | Zendy

Giulio Laurenti | Zendy; Daniel A. Tennant | Zendy

Open Access

Isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), fumarate hydratase (FH): three players for one phenotype in cancer?

Author(s) -

Giulio Laurenti,

Daniel A. Tennant

Publication year - 2016

Publication title -

biochemical society transactions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.562

H-Index - 144

eISSN - 1470-8752

pISSN - 0300-5127

DOI - 10.1042/bst20160099

Subject(s) - isocitrate dehydrogenase , fumarase , citric acid cycle , succinate dehydrogenase , biology , idh1 , tricarboxylic acid , phenotype , enzyme , mitochondrion , isocitrate lyase , malate dehydrogenase , biochemistry , dehydrogenase , metabolic pathway , cancer research , mutation , glyoxylate cycle , gene

In the early 1920s Otto Warburg observed that cancer cells have altered metabolism and from this, posited that mitochondrial dysfunction underpinned the aetiology of cancers. The more recent identification of mutations of mitochondrial metabolic enzymes in a wide range of human cancers has now provided a direct link between metabolic alterations and cancer. In this review we discuss the consequences of dysfunction of three metabolic enzymes involved in or associated with the tricarboxylic acid (TCA) cycle: succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH) focusing on the similarity between the phenotypes of cancers harbouring these mutations.

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