Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation | Zendy

Jessica G. Hardy | Zendy; Chris J. Norbury | Zendy

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Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation

Author(s) -

Jessica G. Hardy,

Chris J. Norbury

Publication year - 2016

Publication title -

biochemical society transactions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.562

H-Index - 144

eISSN - 1470-8752

pISSN - 0300-5127

DOI - 10.1042/bst20160078

Subject(s) - cleavage and polyadenylation specificity factor , polyadenylation , cleavage (geology) , cleavage factor , cleavage stimulation factor , regulator , microbiology and biotechnology , biology , gene , computational biology , genetics , gene expression , messenger rna , paleontology , fracture (geology)

Most mammalian protein coding genes are subject to alternative cleavage and polyadenylation (APA), which can generate distinct mRNA 3'UTRs with differing regulatory potential. Although this process has been intensely studied in recent years, it remains unclear how and to what extent cleavage site selection is regulated under different physiological conditions. The cleavage factor Im (CFIm) complex is a core component of the mammalian cleavage machinery, and the observation that its depletion causes transcriptome-wide changes in cleavage site use makes it a key candidate regulator of APA. This review aims to summarize current knowledge of the CFIm complex, and explores the evidence surrounding its potential contribution to regulation of APA.

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