Transport mechanism of a glutamate transporter homologue GltPh | Zendy

Yurui Ji | Zendy; Vincent L. G. Postis | Zendy; Yingying Wang | Zendy; Mark Bartlam | Zendy; Adrian Goldman | Zendy

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Transport mechanism of a glutamate transporter homologue GltPh

Author(s) -

Yurui Ji,

Vincent L. G. Postis,

Yingying Wang,

Mark Bartlam,

Adrian Goldman

Publication year - 2016

Publication title -

biochemical society transactions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.562

H-Index - 144

eISSN - 1470-8752

pISSN - 0300-5127

DOI - 10.1042/bst20160055

Subject(s) - pyrococcus horikoshii , transporter , glutamate receptor , excitatory amino acid transporter , neurotransmitter transporter , chemistry , biochemistry , neurotransmitter , biology , biophysics , neuroscience , central nervous system , enzyme , gene , receptor

Glutamate transporters are responsible for uptake of the neurotransmitter glutamate in mammalian central nervous systems. Their archaeal homologue GltPh, an aspartate transporter isolated from Pyrococcus horikoshii, has been the focus of extensive studies through crystallography, MD simulations and single-molecule FRET (smFRET). Here, we summarize the recent research progress on GltPh, in the hope of gaining some insights into the transport mechanism of this aspartate transporter.

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