Lessons from making the Structural Classification of Proteins (SCOP) and their implications for protein structure modelling | Zendy

Antonina Andreeva | Zendy

Open Access

Lessons from making the Structural Classification of Proteins (SCOP) and their implications for protein structure modelling

Author(s) -

Antonina Andreeva

Publication year - 2016

Publication title -

biochemical society transactions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.562

H-Index - 144

eISSN - 1470-8752

pISSN - 0300-5127

DOI - 10.1042/bst20160053

Subject(s) - structural genomics , computational biology , structural classification of proteins database , protein structure , computer science , biology , biochemistry

The Structural Classification of Proteins (SCOP) database has facilitated the development of many tools and algorithms and it has been successfully used in protein structure prediction and large-scale genome annotations. During the development of SCOP, numerous exceptions were found to topological rules, along with complex evolutionary scenarios and peculiarities in proteins including the ability to fold into alternative structures. This article reviews cases of structural variations observed for individual proteins and among groups of homologues, knowledge of which is essential for protein structure modelling.

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