Structural advances on titin: towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding | Zendy

Thomas Zacharchenko | Zendy; Eleonore von Castelmur | Zendy; Daniel J. Rigden | Zendy; Olga Mayans | Zendy

Open Access

Structural advances on titin: towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding

Author(s) -

Thomas Zacharchenko,

Eleonore von Castelmur,

Daniel J. Rigden,

Olga Mayans

Publication year - 2015

Publication title -

biochemical society transactions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.562

H-Index - 144

eISSN - 1470-8752

pISSN - 0300-5127

DOI - 10.1042/bst20150084

Subject(s) - titin , myofilament , sarcomere , myofibril , nanotechnology , scaffold , chemistry , biophysics , actin , materials science , microbiology and biotechnology , biology , engineering , myocyte , biochemistry , biomedical engineering

Titin is a gigantic filamentous protein of the muscle sarcomere that plays roles in myofibril mechanics and homoeostasis. 3D-structures of multi-domain fragments of titin are now available that start revealing the molecular mechanisms governing its mechanical and scaffolding functions. This knowledge is now being translated into the fabrication of self-assembling biopolymers. Here we review the structural advances on titin, the novel concepts derived from these and the emerging translational avenues.

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