Decoding RAS isoform and codon-specific signalling | Zendy

Anna U. Newlaczyl | Zendy; Fiona E. Hood | Zendy; Judy M. Coulson | Zendy; Ian A. Prior | Zendy

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Decoding RAS isoform and codon-specific signalling

Author(s) -

Anna U. Newlaczyl,

Fiona E. Hood,

Judy M. Coulson,

Ian A. Prior

Publication year - 2014

Publication title -

biochemical society transactions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.562

H-Index - 144

eISSN - 1470-8752

pISSN - 0300-5127

DOI - 10.1042/bst20140057

Subject(s) - gene isoform , gene , biology , signalling , computational biology , encode , genetics , microbiology and biotechnology

RAS proteins are key signalling hubs that are oncogenically mutated in 30% of all cancer cases. Three genes encode almost identical isoforms that are ubiquitously expressed, but are not functionally redundant. The network responses associated with each isoform and individual oncogenic mutations remain to be fully characterized. In the present article, we review recent data defining the differences between the RAS isoforms and their most commonly mutated codons and discuss the underlying mechanisms.

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