Open AccessA new discovery of STAT4 single nucleotide polymorphisms associated with hepatocellular carcinoma risk in Chinese Han population: a case–control study
Author(s) -
Chao Xu,
Jieqiong Wu,
Wei Zhang,
Xuesong Feng,
Luyan Zhao,
Feng Huang,
Chao Jiang
Publication year - 2021
Publication title -
bioscience reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 77
eISSN - 1573-4935
pISSN - 0144-8463
DOI - 10.1042/bsr20210124
Subject(s) - single nucleotide polymorphism , odds ratio , genotype , hepatocellular carcinoma , haplotype , snp , medicine , case control study , population , oncology , genetic association , biology , genetics , gene , environmental health
Hepatocellular carcinoma (HCC) is a common fatal malignant tumor worldwide. Signal transducer and activator of transcription 4 (STAT4) is HCC susceptibility gene identified by genome-wide association study. The purpose of the present study was to determine the association between four candidate single nucleotide polymorphisms (SNPs) in STAT4 genes and HCC risk in Chinese Han population.
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