Exploring the mechanism of (-)-Epicatechin on premature ovarian insufficiency based on network pharmacology and experimental evaluation | Zendy

Fei Yan | Zendy; Qi Zhao | Zendy; Huanpeng Gao | Zendy; Xiaomei Wang | Zendy; Ke Xu | Zendy; Yishu Wang | Zendy; Fuguo Han | Zendy; Qingfei Liu | Zendy; Yun Shi | Zendy

Open Access

Exploring the mechanism of (-)-Epicatechin on premature ovarian insufficiency based on network pharmacology and experimental evaluation

Author(s) -

Fei Yan,

Qi Zhao,

Huanpeng Gao,

Xiaomei Wang,

Ke Xu,

Yishu Wang,

Fuguo Han,

Qingfei Liu,

Yun Shi

Publication year - 2021

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20203955

Subject(s) - mechanism (biology) , premature ovarian insufficiency , pharmacology , premature ovarian failure , medicine , computational biology , biology , epistemology , philosophy

Relevant potential targets for EC were obtained based on Traditional Chinese Medicine System Pharmacology Database (TCMSP), a bioinformatics analysis tool for molecular mechanism of Traditional Chinese Medicine (BATMAN-TCM) and STITCH databases. The Online Mendelian Inheritance in Man (OMIM) and GeneCards databases were utilized to screen the known POI-related targets, while Cytoscape software was used for network construction and visualization. Then, the Gene Ontology (GO) and pathway enrichment analysis were carried out by the Database for Annotation, Visualization and Integrated Discovery (DAVID) database. Furthermore, KGN cells were performed to validate the predicted results in oxidative stress (OS) model, and antioxidant effect was examined.

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