Comment on “Expression of CD44 and the survival in glioma: a meta-analysis” | Zendy

Chongxian Hou | Zendy; Lin Han | Zendy; Peng Wang | Zendy; Yong Yang | Zendy; Siyi Cen | Zendy; Dong Zhou | Zendy

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Comment on “Expression of CD44 and the survival in glioma: a meta-analysis”

Author(s) -

Chongxian Hou,

Lin Han,

Peng Wang,

Yong Yang,

Siyi Cen,

Dong Zhou

Publication year - 2020

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20202812

Subject(s) - cd44 , glioma , meta analysis , oncology , survival analysis , medicine , enthusiasm , cancer research , biology , psychology , cell , genetics , social psychology

CD44 has been considered as a cancer stem cell marker in various tumors. With great enthusiasm, we read an article written by Wu et al. entitled "Expression of CD44 and the survival in glioma: a meta-analysis" published in Bioscience Reports. The authors performed meta-analyses to study the prognostic significance of CD44 in gliomas, and drew the conclusion that high expression of CD44 may predict poor survival in glioma, particularly in WHO grade II-III gliomas. However, two major defects exist in the present study, which made the meta-analysis on the prognostic significance of CD44 in all gliomas unreliable. In this commentary, we discussed the limitations and significance of the present study.

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