Long-chain noncoding RNA-GAS5/hsa-miR-138-5p attenuates high glucose-induced cardiomyocyte damage by targeting CYP11B2 | Zendy

Xiaozhen Zhuo | Zendy; Kai Bai | Zendy; Yingxian Wang | Zendy; Peining Liu | Zendy; Wen Xi | Zendy; Jianqing She | Zendy; Junhui Liu | Zendy

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Long-chain noncoding RNA-GAS5/hsa-miR-138-5p attenuates high glucose-induced cardiomyocyte damage by targeting CYP11B2

Author(s) -

Xiaozhen Zhuo,

Kai Bai,

Yingxian Wang,

Peining Liu,

Wen Xi,

Jianqing She,

Junhui Liu

Publication year - 2021

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20202232

Subject(s) - gas5 , tunel assay , apoptosis , diabetic cardiomyopathy , streptozotocin , downregulation and upregulation , long non coding rna , gene knockdown , real time polymerase chain reaction , cancer research , diabetes mellitus , microbiology and biotechnology , chemistry , biology , medicine , endocrinology , cardiomyopathy , gene , biochemistry , heart failure

Diabetic cardiomyopathy (DCM) is one of the complications experienced by patients with diabetes. In recent years, long noncoding RNAs (lncRNAs) have been investigated because of their role in the progression of various diseases, including DCM. The purpose of the present study was to explore the role of lncRNA GAS5 in high glucose (HG)-induced cardiomyocyte injury and apoptosis.

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