KCNQ1OT1 regulates the retinoblastoma cell proliferation, migration and SIRT1/JNK signaling pathway by targeting miR-124/SP1 axis | Zendy

Haitao Zhang | Zendy; Xin Yang | Zendy; Yingying Xu | Zendy; Haijun Li | Zendy

Open Access

KCNQ1OT1 regulates the retinoblastoma cell proliferation, migration and SIRT1/JNK signaling pathway by targeting miR-124/SP1 axis

Author(s) -

Haitao Zhang,

Xin Yang,

Yingying Xu,

Haijun Li

Publication year - 2020

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20201626

Subject(s) - cell growth , cell cycle , microrna , gene knockdown , apoptosis , flow cytometry , retinoblastoma , gene silencing , retinoblastoma protein , carcinogenesis , microbiology and biotechnology , chemistry , biology , biochemistry , gene

Long non-coding RNA (lncRNA) KCNQ1OT1 was reported to be tightly associated with tumorigenesis and progression of multiple cancers. However, the expression and biological functions of KCNQ1OT1 in retinoblastoma (RB) are still unknown. We aim to elucidate the potential function and underlying mechanism of KCNQ1OT1 in regulating the progression of RB.

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