miR-4454 up-regulated by HPV16 E6/E7 promotes invasion and migration by targeting ABHD2/NUDT21 in cervical cancer | Zendy

Hui Wang | Zendy; Hui Hu | Zendy; Zhenzhao Luo | Zendy; Shuiyi Liu | Zendy; Wangze Wu | Zendy; Man Zhu | Zendy; Jing Wang | Zendy; Yingle Liu | Zendy; Zhongxin Lu | Zendy

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miR-4454 up-regulated by HPV16 E6/E7 promotes invasion and migration by targeting ABHD2/NUDT21 in cervical cancer

Author(s) -

Hui Wang,

Hui Hu,

Zhenzhao Luo,

Shuiyi Liu,

Wangze Wu,

Man Zhu,

Jing Wang,

Yingle Liu,

Zhongxin Lu

Publication year - 2020

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20200796

Subject(s) - cancer research , apoptosis , cell growth , biology , suppressor , cervical cancer , cell , microbiology and biotechnology , cell migration , gene , cancer , genetics

The abnormal expression of HPV16 E6/E7 activates oncogenes and/or inactivates tumor suppressor genes, resulting in the selective growth and malignant transformation of cancer cells. miR-4454 was selected by sequencing due to its abnormal high expression in HPV16 E6/E7 positive CaSki cell compared with HPV16 E6/E7 negative C33A cell. Overexpression of miR-4454 enhances cervical cancer cell invasion and migration. ABHD2 and NUDT21 are identified as a target gene of miR-4454.The effects of ABHD2 and NUDT21 on migration and invasion of CaSki and C33A cells were determined. The dual luciferase and RT-qPCR assays confirmed that miR-4454 might regulate its targets ABHD2 and NUDT21 to promote the proliferation, invasion and migration, whereas, inhibit the apoptosis in CaSki and C33A cells.

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