MIR22HG regulates miR-486/PTEN axis in bladder cancer to promote cell proliferation | Zendy

Qisheng Tang | Zendy; Xue Jiang | Zendy; Shanjin Ma | Zendy; Lei Wang | Zendy; Ruixiao Li | Zendy; Jianjun Ma | Zendy

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MIR22HG regulates miR-486/PTEN axis in bladder cancer to promote cell proliferation

Author(s) -

Qisheng Tang,

Xue Jiang,

Shanjin Ma,

Lei Wang,

Ruixiao Li,

Jianjun Ma

Publication year - 2020

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20193991

Subject(s) - pten , tensin , cell growth , cancer research , microrna , phosphatase , bladder cancer , cell , biology , cancer , microbiology and biotechnology , signal transduction , phosphorylation , gene , pi3k/akt/mtor pathway , genetics

The tumor suppressive role of MIR22HG has been studied in several types of cancer. We analyzed the TCGA dataset and found the down-regulation of MIR22HG in bladder cancer (BC). Bioinformatics analysis predicted the interaction between MIR22HG and miR-486. The direct interaction between MIR22HG and miR-486 was also confirmed by dual luciferase assay. However, overexpression of these two factors did not significantly affect the expression of each other. Interestingly, overexpression of MIR22HG led to up-regulated phosphatase and tensin homolog (PTEN), which is a target of miR-486. In cell proliferation assay, overexpression of MIR22HG and PTEN led to decreased rates of BC cell proliferation. Moreover, overexpression of miR-486 played an opposite role and attenuated the effects of overexpression of MIR22HG and PTEN. Therefore, MIR22HG regulates miR-486/PTEN axis to promote cell proliferation in BC.

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