Open AccessGlycogen synthase kinase 3β promotes osteosarcoma invasion and migration via regulating PTEN and phosphorylation of focal adhesion kinase
Author(s) -
Wei Mai,
Lingyu Kong,
Hao Yu,
Junjie Bao,
Chunyu Song,
Guofan Qu
Publication year - 2021
Publication title -
bioscience reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 77
eISSN - 1573-4935
pISSN - 0144-8463
DOI - 10.1042/bsr20193514
Subject(s) - tensin , pten , osteosarcoma , gsk 3 , focal adhesion , glycogen synthase , cancer research , gsk3b , kinase , transfection , gene knockdown , phosphorylation , metastasis , cell migration , blot , chemistry , gentamicin protection assay , biology , microbiology and biotechnology , signal transduction , cell , cell culture , pi3k/akt/mtor pathway , cancer , biochemistry , apoptosis , gene , genetics
Typical features of human osteosarcoma are highly invasive and migratory capacities. Our study aimed to investigate the roles of glycogen synthase kinase 3β (GSK3β) in human osteosarcoma metastasis.