Open AccessThe mechanism and role of intracellular α-ketoglutarate reduction in hepatic stellate cell activation
Author(s) -
Jianjian Zhao,
Yueping Jiang,
Xueguo Sun,
Xi-Shuang Liu,
Fuguo Liu,
Mingquan Song,
Lingyun Zhang
Publication year - 2020
Publication title -
bioscience reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 77
eISSN - 1573-4935
pISSN - 0144-8463
DOI - 10.1042/bsr20193385
Subject(s) - intracellular , hepatic stellate cell , microbiology and biotechnology , biochemistry , biology , cell culture , chemistry , endocrinology , genetics
The activation of hepatic stellate cells (HSCs) plays a central role in liver fibrosis. α-ketoglutarate is a natural metabolite and previous studies have shown that increase in intracellular α-ketoglutarate can inhibit HSC activation.
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