Astragalus polysaccharide attenuates metabolic memory-triggered ER stress and apoptosis via regulation of miR-204/SIRT1 axis in retinal pigment epithelial cells | Zendy

Qinghua Peng | Zendy; Ping Tong | Zendy; Limin Gu | Zendy; Wenjie Li | Zendy

Open Access

Astragalus polysaccharide attenuates metabolic memory-triggered ER stress and apoptosis via regulation of miR-204/SIRT1 axis in retinal pigment epithelial cells

Author(s) -

Qinghua Peng,

Ping Tong,

Limin Gu,

Wenjie Li

Publication year - 2020

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20192121

Subject(s) - apoptosis , gene knockdown , unfolded protein response , microbiology and biotechnology , annexin , sirtuin 1 , biology , flow cytometry , oxidative stress , chemistry , downregulation and upregulation , biochemistry , gene

'Metabolic memory' of early hyperglycaemic environment has been frequently suggested in the progression of diabetic retinopathy (DR). Retinal pigment epithelial (RPE) cells are crucial targets for DR initiation following hyperglycaemia. Astragalus polysaccharides (APS) has been long used as a traditional Chinese medicine in treating diabetes. In the present study, the preventive effects and mechanisms of APS on metabolic memory-induced RPE cell death were investigated.

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