miR-122/SIRT1 axis regulates chondrocyte extracellular matrix degradation in osteoarthritis | Zendy

Yinwei Bai | Zendy; Kun Chen | Zendy; Jianfeng Zhan | Zendy; Mingxin Wu | Zendy

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miR-122/SIRT1 axis regulates chondrocyte extracellular matrix degradation in osteoarthritis

Author(s) -

Yinwei Bai,

Kun Chen,

Jianfeng Zhan,

Mingxin Wu

Publication year - 2020

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20191908

Subject(s) - aggrecan , gene knockdown , extracellular matrix , chondrocyte , chemistry , matrix metalloproteinase , microbiology and biotechnology , osteoarthritis , cartilage , microrna , type ii collagen , gene expression , proteoglycan , gene , biology , biochemistry , medicine , pathology , anatomy , articular cartilage , alternative medicine

MicroRNAs (miRNAs) are involved in the pathogenesis of osteoarthritis (OA). The present study aimed to investigate the potential function of miR-122 in the development of OA and its potential molecular mechanisms.

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