Open AccessEffect of celecoxib in treatment of burn-induced hypermetabolism
Author(s) -
Shubo Zhuang,
Jiake Chai,
Lingying Liu,
Huinan Yin,
Yonghui Yu
Publication year - 2020
Publication title -
bioscience reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 77
eISSN - 1573-4935
pISSN - 0144-8463
DOI - 10.1042/bsr20191607
Subject(s) - hypermetabolism , celecoxib , burn out , medicine , chemistry , pharmacology , intensive care medicine , clinical psychology
Cyclooxygenase-2 (COX-2) catalyzes the rate-limiting step of prostanoid biosynthesis. Under pathologic conditions, COX-2 activity can produce reactive oxygen species and toxic prostaglandin metabolites that exacerbate injury and metabolic disturbance. The present study was performed to investigate the effect of Celecoxib (the inhibitor of COX-2) treatment on lipolysis in burn mice.
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