Pooled analysis of the Xpert MTB/RIF assay for diagnosing tuberculous meningitis | Zendy

Yuan-Zhi Chen | Zendy; Lichang Sun | Zendy; Yaohong Wen | Zendy; Zhongwei Li | Zendy; Shu-Jin Fan | Zendy; Hong-Kun Tan | Zendy; Min Qiu | Zendy; ZhiYong Pan | Zendy; Qin Li | Zendy; Yanzhen Zhao | Zendy; Zhenxing Li | Zendy; XuGuang Guo | Zendy

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Pooled analysis of the Xpert MTB/RIF assay for diagnosing tuberculous meningitis

Author(s) -

Yuan-Zhi Chen,

Lichang Sun,

Yaohong Wen,

Zhongwei Li,

Shu-Jin Fan,

Hong-Kun Tan,

Min Qiu,

ZhiYong Pan,

Qin Li,

Yanzhen Zhao,

Zhenxing Li,

XuGuang Guo

Publication year - 2019

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20191312

Subject(s) - medicine , diagnostic odds ratio , likelihood ratios in diagnostic testing , tuberculous meningitis , confidence interval , odds ratio , receiver operating characteristic , meta analysis , tuberculosis , pooled analysis , meningitis , pathology , surgery

Tuberculous meningitis (TBM) is one of the most serious types of extrapulmonary tuberculosis. However, low sensitivity of culture of cerebrospinal fluid (CSF) increases the difficulty in clinical diagnosis, leading to diagnostic delay, and misdiagnosis. Xpert MTB/RIF assay is a rapid and simple method to detect tuberculosis. However, the efficacy of this technique in diagnosing TBM remains unclear. Therefore, a meta-analysis was conducted to evaluate the diagnostic efficacy of Xpert MTB/RIF for TBM, which may enhance the development of early diagnosis of TBM.

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