Hepatoprotective effect of essential oils of Nepeta cataria L. on acetaminophen-induced liver dysfunction | Zendy

Juan Tan | Zendy; Jing Li | Zendy; Jilei Ma | Zendy; Feng Qiao | Zendy

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Hepatoprotective effect of essential oils of Nepeta cataria L. on acetaminophen-induced liver dysfunction

Author(s) -

Juan Tan,

Jing Li,

Jilei Ma,

Feng Qiao

Publication year - 2019

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20190697

Subject(s) - acetaminophen , chemistry , liver injury , pharmacology , essential oil , hepatoprotection , biochemistry , enzyme , medicine , food science , glutathione

Nepeta cataria L. has long been used in folk food and medicine for several functions. Essential oils (EOs) were extracted from Nepeta cataria L. by supercritical fluid extraction. The results of animal experiments showed that EOs from Nepeta cataria L. significantly attenuated acetaminophen-induced liver damage. Further study confirmed that EOs were able to increase mRNA expression of uridine diphosphate glucuronosyltransferases (UGTs) and sulfotransferases (SULTs), as well as inhibit CYP2E1 activities, and thereby suppressed toxic intermediate formation. Nrf-2 activation might be involved in EOs-induced up-regulation of Phase II enzymes. Collectively, our data provide evidence that EOs protect the liver against acetaminophen-induced liver injury mainly by accelerating acetaminophen harmless metabolism, implying that EOs can be considered as a potential natural resource to develop hepatoprotective agent.

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