High-throughput sequencing analysis of genes encoding the B-lymphocyte receptor heavy-chain CDR3 in renal and peripheral blood of IgA nephropathy | Zendy

Dapeng Chen | Zendy; Zheng Zhang | Zendy; Yue Yang | Zendy; Quan Hong | Zendy; Wenge Li | Zendy; Li Zhuo | Zendy

Open Access

High-throughput sequencing analysis of genes encoding the B-lymphocyte receptor heavy-chain CDR3 in renal and peripheral blood of IgA nephropathy

Author(s) -

Dapeng Chen,

Zheng Zhang,

Yue Yang,

Quan Hong,

Wenge Li,

Li Zhuo

Publication year - 2019

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20190482

Subject(s) - gene , peripheral blood , nephropathy , dna sequencing , biology , lymphocyte , receptor , immunology , genetics , computational biology , endocrinology , diabetes mellitus

IgA nephropathy (IgAN) is one of the most common chronic glomerulonephritis. Its etiology and pathogenesis remain unclear. We thus explored the immune repertoire of the B-cell receptor (BCR) and the heavy-chain complementarity-determining region 3 (CDR3) in renal tissue and peripheral blood of IgAN patients.

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