Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice | Zendy

Bing Wan | Zendy; Yan Li | Zendy; Shuangshuang Sun | Zendy; Yang Yang | Zendy; Yanling Lv | Zendy; Li Wang | Zendy; Meijuan Song | Zendy; Meizi Chen | Zendy; Chengjiang Wu | Zendy; Hangcheng Pan | Zendy; Xiuwei Zhang | Zendy

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Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice

Author(s) -

Bing Wan,

Yan Li,

Shuangshuang Sun,

Yang Yang,

Yanling Lv,

Li Wang,

Meijuan Song,

Meizi Chen,

Chengjiang Wu,

Hangcheng Pan,

Xiuwei Zhang

Publication year - 2019

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20190301

Subject(s) - bronchoalveolar lavage , proinflammatory cytokine , malondialdehyde , lipopolysaccharide , myeloperoxidase , lung , chemistry , pharmacology , inflammation , superoxide dismutase , immunology , medicine , biochemistry , enzyme , oxidative stress

The present study aimed to investigate the protective effects of ganoderic acid A (GAA) on lipopolysaccharide (LPS)-induced acute lung injury. In mouse model of LPS-induced acute lung injury, we found that GAA led to significantly lower lung wet-to-dry weight ratio and lung myeloperoxidase activity, and attenuated pathological damages. In addition, GAA increased superoxide dismutase activity, but decreased malondialdehyde content and proinflammatory cytokines levels in the bronchoalveolar lavage fluid. Mechanistically, GAA reduced the activation of Rho/ROCK/NF-κB pathway to inhibit LPS-induced inflammation. In conclusion, our study suggests that GAA attenuates acute lung injury in mouse model via the inhibition of Rho/ROCK/NF-κB pathway.

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