LncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis | Zendy

Tao Huang | Zendy; Jian Wang | Zendy; Yuan Zhou | Zendy; Yi Zhao | Zendy; Donghua Hang | Zendy; Yun Cao | Zendy

Open Access

LncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis

Author(s) -

Tao Huang,

Jian Wang,

Yuan Zhou,

Yi Zhao,

Donghua Hang,

Yun Cao

Publication year - 2019

Publication title -

bioscience reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 77

eISSN - 1573-4935

pISSN - 0144-8463

DOI - 10.1042/bsr20182454

Subject(s) - chondrocyte , apoptosis , osteoarthritis , microbiology and biotechnology , chemistry , cartilage , cancer research , biology , medicine , biochemistry , anatomy , pathology , alternative medicine

Long non-coding RNAs (lncRNA) CASC2 is a key player in cancer biology. Our new findings showed that both lncRNA CASC2 and IL-17 were up-regulated in plasma of osteoarthritis patients. Plasma levels of lncRNA CASC2 and IL-17 were significantly and positive correlated only in osteoarthritis patients. Overexpression of lncRNA CASC2 led to up-regulated expression of IL-17 in cells of human chondrocyte cell line CHON-001 (ATCC ® CRL-2846™). In addition, overexpression of lncRNA CASC2 inhibited the proliferation, and promoted the apoptosis of chondrocyte. Therefore, lncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis.

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